Relaxation and immunity-enhancing effects GABA administration in humans

The effect of orally administered gamma-aminobutyric acid (GABA) on relaxation and immunity during stress has been studied in humans. Two studies were conducted. In the first, the effect of GABA ingestion was studied in 13 subjects on their brain waves. Electroencephalograms (EEG) were obtained after 3 tests on each subject as follows: Water only, GABA, or L-theanine ingestion.

After 60 minutes of administration, GABA significantly increased alpha waves and decreased beta waves compared with water or L-theanine. These results show that GABA not only induces relaxation but also reduces anxiety. The second study was conducted to investigate the role of the relaxing and anxiolytic effects of GABA ingestion on the immunity of stressed volunteers.

Eight acrophobic volunteers were divided into 2 groups (placebo and GABA). All subjects crossed a suspension bridge as a stress stimulus. Immunoglobulin A (IgA) levels in their saliva were monitored while crossing the bridge. The placebo group showed a significant decrease in their IgA levels, while the GABA group showed significantly higher levels. Z

In conclusion, GABA could effectively act as a natural relaxant and its effect could be seen within 1 hour after its administration to induce relaxation and reduce anxiety. In addition, the administration of GABA was able to strengthen immunity under stressful conditions.


Biofactors: Relaxation and Immunity Enhancement Effects of Gamma-Aminobutyric Acid (GABA) Administration in Humans

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