Bye bye, booze!
It is to examine whether the conclusion of a recent systematic review and network meta-analysis (Cipriani et al.) that antidepressants are more effective than placebo for adult depression was supported by the evidence.
Several methodologic limitations in the evidence base for antidepressants were either not recognized or underestimated in the systematic review by Cipriani et al. The effect size for antidepressants versus placebo on investigator-rated depression symptom scales was higher in studies with a “placebo run-in” study design than in studies without a placebo run-in design (p=0.05). The effect size of antidepressants was higher in published studies than in unpublished studies (p<0.0001). Outcome data reported by Cipriani et al. differed from clinical trial reports in 12 (63%) of 19 studies. The certainty of the evidence for the placebo-controlled comparisons should be very low according to GRADE due to a high risk of bias, indirectness of evidence, and publication bias. The mean difference between antidepressants and placebo on the 17-item Hamilton Depression Rating Scale (range 0-52 points) was 1.97 points (95% CI 1.74 to 2.21).
The evidence does not support definitive conclusions regarding the benefits of antidepressants for depression in adults. It is unclear whether antidepressants are more effective than placebo.
BMJ: Considering the methodological limitations in the evidence base of antidepressants for depression: a reanalysis of a network meta-analysis
Found at Alkohol adé (german)
Powered by BetterDocs
(Use Cropper to set image and use mouse scroller for zoom image.)
Already have an account? Login
This site is still under development. Feel free to look around and don't hesitate to give us feedback, you'll find a form at the end of each page.
Nevertheless, we activate a few cookies, and these cookies could change due to the fact. that it's a development-site.
Bye bye booze needs cookies, too. However, we try only to activate as few as possible technically necessary cookies so that your visit to this site cannot be tracked as far as possible by third parties.
However, we do need a few - e.g. to display this legal notice or to care for that you do not have to log in again for each page or see this popup again for each page.
As soon as you click on an external link or video, however, cookies may be set by the operators of these sites, which we cannot influence. Learn more on our privacy page.