Skip to content

Review of thiamine deficiency disorders: Wernicke’s encephalopathy and Korsakoff’s psychosis.

Wernicke encephalopathy (WE) and Korsakoff psychosis (KP), collectively referred to as Wernicke-Korsakoff syndrome (WKS), are distinct but overlapping neuropsychiatric disorders associated with thiamine deficiency.

Thiamine pyrophosphate, the biologically active form of thiamine, is essential for several biochemical pathways involved in carbohydrate utilization. Both genetic susceptibilities and acquired deficiencies resulting from alcoholic and nonalcoholic factors are associated with thiamine deficiency or its impaired utilization.

WKS is underdiagnosed because of inconsistent clinical presentation and overlap of symptoms with other neurologic disorders. Identification and individualized treatment of WWS based on etiology is critical to prevent the development of the amnestic state associated with KP in genetically predisposed individuals.

In this review, we bring together existing data from animal and human models to elucidate the etiopathogenesis, diagnosis, and therapeutic interventions for WE and KP.

Review of Thiamine Deficiency Disorders: Wernicke Encephalopathy and Korsakoff Psychosis.

Powered by BetterDocs

Close Popup

Bye bye booze needs a few cookies, too.

However, we try only to activate as few as possible technically necessary cookies so that your visit to this site cannot be tracked as far as possible by third parties. We do not share any information about your visit with anyone.

But even we we do need a few - e.g. to display this legal notice or to care for that you do not have to log in again for each page or see this popup again for each page.

As soon as you click on an external link or video, cookies may be set by the operators of these sites, which we cannot influence. Learn more on our privacy page.

Close Popup