Bye bye, booze!
Sober up with science
Experimental evidence suggests that components of the hypothalamic-pituitary-adrenal (HPA) axis and the endogenous opioid system, such as beta-endorphin (beta-END), influence alcohol consumption, whereas chronic alcohol abuse alters the activity of both systems.
In addition, sex and age differences have been found in HPA axis activity under basal conditions in response to stress and acute alcohol problems. The aim of the present studies was to examine the hypothesis that chronic alcohol abuse alters HPA axis and pituitary-beta-END activity as a function of severity of alcohol abuse, sex, and age.
Results: Plasma ACTH and beta-END levels were significantly lower in women than in men of all ages and drinking categories. Plasma cortisol levels were higher in 18- to 29-year-old female subjects than in 18- to 29-year-old male subjects. Plasma ACTH and beta-END levels were lower, whereas plasma cortisol levels were higher in heavy drinkers than in nondrinkers. This decrease in plasma ACTH and beta-END levels with heavy drinking was more pronounced in female subjects in the 30-44 and 45-60 age groups than in male subjects.
Alcohol Clin Exp Res.: Effect of Chronic Alcohol Consumption on the Activity of the Hypothalamic-Pituitary-Adrenal Axis and Pituitary Beta-Endorphin as a Function of Alcohol Intake, Age, and Gender
Found at Alkohol adé (german)
Powered by BetterDocs
This site is still under development. Feel free to look around and don't hesitate to give us feedback, you'll find a form at the end of each page.
Nevertheless, we activate a few cookies, and these cookies could change due to the fact. that it's a development-site.
Bye bye booze needs cookies, too. However, we try only to activate as few as possible technically necessary cookies so that your visit to this site cannot be tracked as far as possible by third parties.
However, we do need a few - e.g. to display this legal notice or to care for that you do not have to log in again for each page or see this popup again for each page.
As soon as you click on an external link or video, however, cookies may be set by the operators of these sites, which we cannot influence. Learn more on our privacy page.