Skip to content

Tobacco smoking interferes with GABA(A) receptor readjustment during prolonged alcohol withdrawal

  • by

Tobacco smoking interferes with GABA(A) receptor readjustment during prolonged alcohol withdrawal

The researchers conducted parallel studies in human subjects and nonhuman primates to examine the differential effects of tobacco and nicotine smoking on changes in GABA(A) receptor availability during acute and prolonged alcohol withdrawal.

They report that alcohol withdrawal with or without concurrent tobacco smoking/nicotine use resulted in significant increases in GABA(A) receptor levels during the first week of withdrawal. After prolonged withdrawal, GABA(A) receptor levels returned to normal in alcohol-dependent nonsmokers, but alcohol-dependent smokers had significant and persistent increases in GABA(A) receptors associated with craving for alcohol and cigarettes.

These data suggest that tobacco smoke constituents other than nicotine block recovery of GABA(A) receptor systems during sustained alcohol abstinence, contributing to alcohol relapse and smoking maintenance.

Tobacco smoking interferes with GABAAreceptor neuroadaptations during prolonged alcohol withdrawal.

Powered by BetterDocs

This site is still under development. Feel free to look around and don't hesitate to give us feedback, you'll find a form at the end of each page.

Nevertheless, we activate a few cookies, and these cookies could change due to the fact. that it's a development-site.


Bye bye booze needs cookies, too. However, we try only to activate as few as possible technically necessary cookies so that your visit to this site cannot be tracked as far as possible by third parties.

 

However, we do need a few - e.g. to display this legal notice or to care for that you do not have to log in again for each page or see this popup again for each page.

 

As soon as you click on an external link or video, however, cookies may be set by the operators of these sites, which we cannot influence. Learn more on our privacy page.