Skip to content

Arginine reverses ethanol-induced inflammatory and fibrotic changes in the liver

Arginine reverses alcohol-induced damage to the liver – even though alcohol continues to be ingested. This is the result of a study on rats.

The researchers gave the test animals different amounts of alcohol and arginine and measured inflammation levels; later, they analyzed the liver tissue to see how severe the damage was. “After arginine administration, there was a marked improvement in pathological changes, accompanied by decreased endotoxin levels, lipid peroxidation, activation of nuclear factor-kappaB, tumor necrosis factor-alpha, cyclooxygenase-2, inducible nitric oxide and nitrotyrosine staining,” they write.

They are still puzzling over the mechanism in their article – either the arginine acts directly, or indirectly by increasing nitric oxide.


J Pharmacol Exp Ther.: Arginine reverses ethanol-induced inflammatory and fibrotic changes in liver despite continued ethanol administration

Powered by BetterDocs

Close Popup

Bye bye booze needs a few cookies, too.

However, we try only to activate as few as possible technically necessary cookies so that your visit to this site cannot be tracked as far as possible by third parties. We do not share any information about your visit with anyone.

But even we we do need a few - e.g. to display this legal notice or to care for that you do not have to log in again for each page or see this popup again for each page.

As soon as you click on an external link or video, cookies may be set by the operators of these sites, which we cannot influence. Learn more on our privacy page.


Close Popup