Bye bye, booze!
The present work aimed to investigate the protective effect of L-theanine on cognitive impairment induced by chronic restraint stress (CRS) in mice. Stress was induced by restraining animals in well-ventilated polypropylene tubes (3.2 cm diameter × 10.5 cm length) for 8 h once daily for 21 consecutive days.
L-theanine (2 and 4 mg/kg) was administered 30 min before animals were subjected to acute immobilized stress. At week 4, mice were subjected to a Morris water maze and step-through tests to measure cognitive function, followed by oxidative parameters and then corticosterone and catecholamines (norepinephrine and dopamine).
Our results showed that cognitive performance was significantly deteriorated in the CRS group, accompanied by noticeable changes in oxidative parameters and catecholamine levels in the hippocampus and cerebral cortex, as well as serum corticosterone and catecholamine levels. However, L-theanine treatment showed not only reversal of CRS-induced cognitive impairment and oxidative damage, but also reversal of abnormal serum corticosterone levels and abnormal brain and serum catecholamine levels.
This study indicated the protective effect of L-theanine against CRS-induced cognitive impairment in mice.
Brain Res.: Protective effect of l-theanine on chronic restraint stress-induced cognitive impairments in mice
Found at Alkohol adé (german)
Powered by BetterDocs
(Use Cropper to set image and use mouse scroller for zoom image.)
Already have an account? Login
This site is still under development. Feel free to look around and don't hesitate to give us feedback, you'll find a form at the end of each page.
Nevertheless, we activate a few cookies, and these cookies could change due to the fact. that it's a development-site.
Bye bye booze needs cookies, too. However, we try only to activate as few as possible technically necessary cookies so that your visit to this site cannot be tracked as far as possible by third parties.
However, we do need a few - e.g. to display this legal notice or to care for that you do not have to log in again for each page or see this popup again for each page.
As soon as you click on an external link or video, however, cookies may be set by the operators of these sites, which we cannot influence. Learn more on our privacy page.