The researchers conducted experiments in mice and rats to investigate the nootropic and antianxiety properties of the endogenous ligands of nicotinamide and inosine benzodiazepine receptors and their new structural analogues – NMF and AZN.
They showed that they have obvious antihypoxic and anxiolytic effects. NMF and AZN, administered at doses 10-fold lower than endogenous benzodiazepine ligands, appeared more active than these compounds and almost similar to diazepam in terms of activity.
According to the scientists, the obtained data indicate the possibility of a targeted search for new effective psychotropic and nootropic substances in the series of compounds structurally related to the endogenous ligand of benzodiazepine receptors.
