In experiments in mice, scientists showed that nicotinamide at intraperitoneally administered doses of 250-500 mg/kg increased the latency of clonic-tonic convulsions without affecting their expressivity and mortality.
At a dose of 1000 mg/kg, nicotinamide prevented clonic convulsions and mortality and significantly increased convulsion latency and longevity in animals poisoned with thiosemicarbazide and strychnine.
The significance of the nicotinamide effect depended on the time of administration.
