Glutamate diethyl ester, a specific glutamate antagonist, attenuated the seizures and decrease in behavioral activity observed in mice during withdrawal. Before withdrawal, ethanol-dependent animals were hypersensitive to kainic acid, a potent glutamate agonist, but they were not hypersensitive to the anticonvulsant pentylenetetrazol.
These findings suggest that hypersensitivity to glutamate develops during ethanol dependence and that this phenomenon contributes to the signs of ethanol withdrawal.
Pharmacology Biochemistry and Behavior | Glutamic acid and ethanol dependence
Found at Alkohol adé (german)
