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Topic starter
05/02/2021 8:37 pm
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Tyrosine hydroxylase is the rate-limiting enzyme of catecholamine biosynthesis; it uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to DOPA. Its amino-terminal 150 amino acids comprise a domain whose structure is involved in regulating the activity of the enzyme. Modes of regulation include phosphorylation by multiple kinases at 4 different serine residues and dephosphorylation by…
