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30/04/2021 1:14 pm
Recent evidence suggests that epigenetic regulation is dependent on metabolic state and implicates specific metabolic factors in neuronal functions that control behavior. In neurons, acetylation of histones relies on the metabolite acetyl-CoA, which is produced from acetate by chromatin-bound acetyl-CoA synthetase 2 (ACSS2)2. Of note, degradation of alcohol in the liver leads to a rapid…
